In vivo rAAV-mediated human TGF-β overexpression reduces perifocal osteoarthritis and improves osteochondral repair in a large animal model at one year.

S Schrenker,M Cucchiarini,L Goebel,T Oláh,J K Venkatesan,G Schmitt,S Speicher-Mentges, J Maihöfer,L Gao,D Zurakowski, M D Menger,M W Laschke,H Madry

Osteoarthritis and cartilage（2023）

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摘要

rAAV-hTGF-β treatment improves long-term osteochondral repair and delays the progression of perifocal OA in a translational model. These findings have considerable potential for targeted molecular approaches to treat focal osteochondral defects.

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关键词

Cartilage repair,Large animal model,Osteoarthritis,Osteochondral defects,TGF-β,rAAV

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