Ventilator-induced Lung Injury Is Modulated by the Circadian Clock.

Matthias Felten,Sebastian Ferencik,Luiz-Gustavo Teixeira Alves,Eleftheria Letsiou,Jasmin Lienau,Holger C Müller-Redetzky, Alina Katharina Langenhagen, Anne Voß,Kristina Dietert,Olivia Kershaw,Achim D Gruber,Laura Michalick,Wolfgang M Kuebler,Bharath Ananthasubramaniam,Bert Maier, Henriette Uhlenhaut,Achim Kramer,Martin Witzenrath

American journal of respiratory and critical care medicine（2022）

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摘要

Inflammatory response and lung barrier dysfunction upon mechanical ventilation exhibit diurnal variations, regulated by the circadian clock. mice are less susceptible to ventilation-induced pathology and lack circadian variation of severity compared with mice. Our data suggest that the internal clock in myeloid cells is an important modulator of ventilator-induced lung injury.

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关键词

Bmal1,acute respiratory distress syndrome,animal model,circadian rhythm,mechanical ventilation

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