Blockade of orexin receptor type-1 by SB-334867 and activation of orexin receptor type-2 attenuate morphine tolerance in rats.

Ercan Ozdemir,Tayfun Baser,Ahmet Sevki Taskiran

Physiology international（2022）

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摘要

The results of this study demonstrated that co-administration of SB-334867 and orexin-B with morphine attenuated morphine tolerance. Further studies are needed to elucidate the details of the interaction between orexin receptors and the opioidergic system.

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关键词

SB-334867,morphine tolerance,orexin receptors,orexin-A,orexin-B

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