The Impact of Targetable Mutations on Clinical Outcomes of Metastatic Epidural Spinal Cord Compression in Patients With Non-Small-Cell Lung Cancer Treated With Hybrid Therapy (Surgery Followed by Stereotactic Body Radiation Therapy).

Vikram B Chakravarthy,Benjamin Schachner,Anubhav G Amin,Anne S Reiner,Yoshiya Yamada,Adam Schmitt,Daniel S Higginson,Ilya Laufer,Mark H Bilsky,Ori Barzilai

Neurosurgery（2023）

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摘要

Hybrid therapy in NSCLC resulted in 95% local control at 2 years after surgery. EGFR treatment-naïve patients initiating therapy after hybrid therapy had significantly improved survival advantage. EGFR-targeted therapy initiated before hybrid therapy did not confer survival benefit.

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关键词

Oncology,Non-small-cell lung cancer,Spine,Metastatic spinal cord compression,EGFR,Stereotactic body radiotherapy

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