ENO1 expression and Erk phosphorylation in PDAC and their effects on tumor cell apoptosis in a hypoxic microenvironment.

Huizhi Sun,Jing Mo,Runfen Cheng,Fan Li,Yue Li,Yuhong Guo,Yanlei Li,Yanhui Zhang,Xiaoyu Bai,Yalei Wang,Xueyi Dong,Danfang Zhang,Jihui Hao

Cancer biology & medicine（2022）

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摘要

Hypoxia-induced ENO1 expression promotes ERK phosphorylation and inhibits apoptosis, thus leading to PDAC survival and invasion. These results suggest that ENO1 is a potential therapeutic target for PDAC.

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关键词

ENO1,Erk phosphorylation,Pancreatic cancer,apoptosis,hypoxia

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