DNA-Dependent Protein Kinase Mediates YB-1 (Y-Box Binding Protein)-Induced Double Strand Break Repair.

Till Nöthen,Mohsen Abdi Sarabi,Sönke Weinert,Werner Zuschratter,Ronnie Morgenroth,Peter R Mertens,Ruediger C Braun-Dullaeus,Senad Medunjanin

Arteriosclerosis, thrombosis, and vascular biology（2023）

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摘要

DNA-PK directly phosphorylates YB-1 and, this way, modulates YB-1 function. This interaction could be demonstrated in vivo, and colocalization in human atherosclerotic plaques suggests clinical relevance of our finding. Phosphorylation of YB-1 by DNA-PK may represent a novel mechanism governing atherosclerotic plaque progression.

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关键词

cell proliferation,immunoblotting,luciferase,phosphorylation,staining

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