Isoflavone daidzein ameliorates renal dysfunction and fibrosis in a postmenopausal rat model: Intermediation of angiotensin AT1 and Mas receptors and microRNAs 33a and 27a.

Majid Askaripour,Hamid Najafipour,Shadan Saberi,Saleh Yazdani,Saeideh Jafarinejad-Farsangi,Soodeh Rajabi,Elham Jafari,Paul Proost,Sofie Struyf,Fariba Poosti

Iranian journal of basic medical sciences（2022）

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摘要

Compared with E2, daidzein efficiently ameliorated renal dysfunction, fibrosis, and apoptosis through modulation of miR-33a and miR-27a expression and their crosstalk with AT1R and MasR. Therefore, daidzein might be a promising candidate for treating CKD in postmenopausal and older women.

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关键词

Angiotensin receptor,Apoptosis,Daidzein,Ovariectomy,Renal fibrosis,microRNAs

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