Photoactivatable metal organic framework for synergistic ferroptosis and photodynamic therapy using 450 nm laser

•450 nm laser PDT induced more ROS production and cell death than 630 nm laser PDT.•HAFeR increased cellular labile iron pool and made cells sensitive to ferroptosis.•HAFeR produced massive ROS even in hypoxic environment through Type I and Type II PDT.•Under 450 nm laser, HAFeR induced cell apoptosis and ferroptosis concurrently.•450 nm laser is an appropriate source for superficial and intraluminal tumor PDT.