HSP70 and TNF Loci Polymorphism Associated with the Posner-Schlossman Syndrome in a Southern Chinese Population.

Previous studies have shown that gene polymorphisms are associated with the pathogenesis of the Posner-Schlossman syndrome (PSS). This study was aimed at evaluating the associations between gene polymorphisms and PSS in a southern Chinese Han population. A total of 150 PSS patients and 183 healthy controls were included in this study. Twenty-one single nucleotide polymorphisms (SNPs) of genes (including , , , , , and ) were genotyped using the SNaPshot technique. Our study showed that the frequencies of G allele at rs909253, A allele at rs1041981, and G allele at rs2844484 of in the patient group were significantly higher than those in healthy controls (Corrected  ( ) = 0.040, OR = 1.45; = 0.033, OR = 1.45; = 0.045, OR = 1.58, respectively). The frequency of T allele at rs12190359 of was significantly lower in PSS patients than those in healthy controls ( = 0.018 and OR = 0.10). The frequencies of the CCT haplotype of gene (rs1008438-rs562047-rs12190359) and the ACCCTTT haplotype of gene (rs2227956-rs1043618-rs1008438-rs562047-rs12190359-rs2763979-rs6457452) were significantly lower in PSS patients than those in healthy controls ( = 0.024, OR = 0.10; = 0.048, OR = 0.10, respectively). In conclusion, the G allele at rs909253, A allele at rs1041981, and G allele at rs2844484 of gene might be risk factors for PSS, while the T allele at rs12190359 of gene and specific haplotypes of the and genes might be protective factors for PSS.