Donor chimerism and immune reconstitution following haploidentical transplantation in sickle cell disease.

Yaya Chu,Julie-An Talano,Lee Ann Baxter-Lowe,James W Verbsky,Erin Morris,Harshini Mahanti,Janet Ayello,Carolyn Keever-Taylor,Bryon Johnson,Rona S Weinberg,Qiuhu Shi,Theodore B Moore,Sandra Fabricatore,Brenda Grossman,Carmella van de Ven,Shalini Shenoy,Mitchell S Cairo

Frontiers in immunology（2022）

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摘要

These results suggest that haploidentical transplantation with CD34-enriched cells and peripheral blood mononuclear cell addback results in rapid engraftment, sustained donor chimerism and broad-based immune reconstitution.

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关键词

CD34 enrichment,HLA antibodies,NK,donor chimerism,donor grafts,haploidentical transplantation,immune reconstitution,sickle cell disease

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