Persistent immune response: Twice tumor exfoliation induced by sialic acid–modified vincristine sulfate liposomes

Xinyang Yan,Xin Gao,Xiaoya Li,Qiujun Qiu,Cong Li,Na Yan,Jie Li,Mengyang Liu,Xueying Tang,Xinrong Liu,Yanzhi Song,Yihui Deng

International Journal of Pharmaceutics（2022）

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摘要

Scheme 1. Schematic illustration of Persistent immune response: Twice tumor shed induced by sialic acid–modified vincristine sulfate liposomes. (A) Preparation of SA-CH-modified vincristine sulfate liposomes. (B) Schematic illustration of SA-CH-modified vincristine sulfate liposomes, which effectively target tumor-associated macrophages, improve the tumor immunosuppressive microenvironment, and induce anti-tumor immune responses.

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关键词

Vincristine sulfate liposome,Sucrose octasulfate triethylamine gradient method,Sialic acid,Tumor-associated macrophage,Tumor exfoliation

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