SIRT3 Enhances the Protective Role of Propofol in Postoperative Cognitive Dysfunction via Activating Autophagy Mediated by AMPK/mTOR Pathway.

Shang Li, Yi Zhou,Huaying Hu,Xiaodong Wang,Junjun Xu,Chaobo Bai,Junliang Yuan,Dongliang Zhang

Frontiers in bioscience (Landmark edition)（2022）

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摘要

SIRT3 enhances the protective effect of propofol on POCD by triggering autophagy that eliminates oxidative stress and inhibits the production of pro-inflammatory cytokines.

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关键词

SIRT3,autophagy,postoperative cognitive dysfunction,propofol

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