Cellular senescence marker p16INK4a and NFKB1 gene polymorphisms in lower gastro-intestinal acute graft versus host disease

Adam Kuba,Ludek Raida,Svetlana Brychtova,Patrik Flodr,Frantisek Mrazek,Eva Kriegova,Edgar Faber,Tomas Papajik

Transplant Immunology（2023）

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摘要

•p16INK4a gut expression delays lower gastrointestinal GVHD onset.•p16INK4a negativity increases the risk of high histological grade GVHD.•no clinical variable determined p16INK4a gut expression.•NFKB1 gene polymorphisms were associated with p16INK4a gut expression.

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关键词

Graft versus host disease,Lower-gastrointestinal graft versus host disease,Cellular senescence,p16INK4a,NFKB1 gene

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