Overexpression of Rhodopsin or Its Mutants Leads to Energy Metabolism Dysfunction in 661w Cells.

Yang Liu,Xin Wang,Ruowen Gong,Gezhi Xu,Min Zhu

Investigative ophthalmology & visual science（2022）

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摘要

Our results imply that overexpression of RHO missense mutants have distinct impacts on the two energy metabolic pathways, which might be related to their heterogeneous phenotypes.

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关键词

retinitis pigmentosa,RHO mutants,photoreceptor degeneration,energy metabolism dysfunction

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