Gut microbiota is correlated with gastrointestinal adverse events of metformin in patients with type 2 diabetes.

Yuxin Huang,Xudan Lou,Cuiping Jiang,Xueying Ji,Xiaoming Tao,Jiao Sun,Zhijun Bao

Frontiers in endocrinology（2022）

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摘要

Our data suggest that metformin promotes the secretion of intestinal hormones such as GLP-1 by increasing the abundance of SCFA-producing bacteria, which not only plays an anti-diabetic role, but also may causes gastrointestinal adverse events.

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关键词

gastrointestinal adverse events,gut microbiota,metformin,short-chain fatty acids (SCFAs),type 2 diabetes

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