PTEN Loss Expands the Histopathologic Diversity and Lineage Plasticity of Lung Cancers Initiated by Rb1/Trp53 Deletion.

Letian Zhang,Congrong Liu,Bo Zhang,Jie Zheng,Prashant K Singh,Wiam Bshara,Jianmin Wang,Eduardo Cortes Gomez,Xiaojing Zhang,Yanqing Wang,Xiang Zhu,David W Goodrich

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer（2022）

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摘要

These results identify PTEN loss as a clinically relevant genetic alteration driving the molecular and histopathologic heterogeneity of neuroendocrine lung tumors initiated by Rb1/Trp53 mutations.

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关键词

Genetically engineered mouse models,Small cell lung cancer,Tumor heterogeneity,Tumor suppressor genes

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