Measuring variation in the quality of systemic anti-cancer therapy delivery across hospitals: A national population-based evaluation

•Quality of SACT delivery was evaluated in adjuvant and metastatic colorectal cancer patients.•Variation in toxicity rates across 106 English NHS hospitals was used to explore this.•Adjusted toxicity rates varied from 11% to 49% (adjuvant) and from 25% to 67% (metastatic).•Twelve hospitals had toxicity rates >2SD above the national average, and 11 >2SD below.•Ongoing reporting of this performance indicator can be used for quality improvement.