Primary targeted medical therapy for management of bilateral head and neck lymphatic malformations in infants

Clare M Richardson,Jonathan N Perkins,Kaitlyn Zenner,Catherine Bull,Erika Lutsky,Dana M Jensen,Victoria Dmyterko,James T Bennett,Tara L Wenger,John P Dahl,Juliana Bonilla-Velez,Randall A Bly,Amy E Geddis,Jonathan A Perkins

International Journal of Pediatric Otorhinolaryngology（2023）

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摘要

This study compares patients with BHNLMs (Grade 2) treated with pTMT versus those treated with observation or invasive therapy. Patients treated with pTMT required no surgical or invasive procedural treatment of their malformations, no tracheostomy placement, no unplanned readmissions after discharge, and had no mortalities. Needle aspiration was useful as a therapeutic adjunct for cell-free DNA diagnosis of PIK3CA variants, which guided TMT.

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关键词

Lymphatic malformation,Treatment,Targeted therapy,Surgery,PI3K,Needle aspiration

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