Developmental endothelial locus-1 attenuates palmitate-induced apoptosis in tenocytes through the AMPK/autophagy-mediated suppression of inflammation and endoplasmic reticulum stress.

Tae Jun Park,Seung Yeon Park,Wonjun Cho,Heeseung Oh,Hyun Jung Lee,A M Abd El-Aty,Cemil Bayram,Ji Hoon Jeong,Tae Woo Jung

Bone & joint research（2022）

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摘要

These results revealed that DEL-1 suppresses inflammation and ER stress, thereby attenuating tenocyte apoptosis through AMPK/autophagy-mediated signalling. Thus, regular exercise or administration of DEL-1 may directly contribute to improving tendinitis exacerbated by obesity and insulin resistance.Cite this article: 2022;11(12):854-861.

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关键词

AMPK,Apoptosis,Autophagy,DEL-1,ER stress,Obesity,RNA,Tenocytes,Western blotting,apoptosis,autophagy,caspase 3,inflammation,insulin,staining,tendinitis

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