Histone deacetylase activity is a novel target for epithelial barrier defects in patients with eosinophilic chronic rhinosinusitis with nasal polyps.

Su Duan,Xinling Han,Jian Jiao,Ming Wang,Ying Li,Yang Wang,Luo Zhang

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology（2023）

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摘要

Our data suggest that eosinophilia and HDACs influence epithelial barrier function in CRSwNP patients by regulating TJ protein expression. Targeting HDACs with specific inhibitors may be a potential treatment option for patients with eosinophilic CRSwNP.

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关键词

eosinophilic chronic rhinosinusitis with nasal polyps,epithelial barrier,histone deacetylases,noneosinophilic chronic rhinosinusitis with nasal polyps,tight junctions

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