Novel pathways of fluoride-induced hepatotoxicity: P53-dependent ferroptosis induced by the SIRT1/FOXOs pathway and Nrf2/HO-1 pathway

Dongxu Wang,Kai Yin,Yue Zhang,Hongmin Lu,Lulu Hou,Hongjing Zhao,Mingwei Xing

Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology（2023）

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摘要

Fluoride (F) is an environmental pollutant that continues to threaten human health. Long-term or excessive fluoride exposure can cause a series of acute or chronic systemic and organ-specific diseases.

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关键词

Fluoride excess,Liver damage,Ferroptosis,FOXOs pathway,P53

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