PNPLA3 allele frequency has no impact on biliary bile acid composition or disease course in patients with primary sclerosing cholangitis.

Martti Färkkilä,Hannu Kautiainen,Andrea Tenca,Kalle Jokelainen,Johanna Arola

PloS one（2022）

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摘要

The PNPLA3 I148M variant had no significant impact on on bile composition, including UDCA content, clinical outcomes, progression of liver fibrosis, hepatobiliary cancer risk, liver transplantation, or overall survival.

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biliary bile acid composition

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