Intralipid® improves left ventricular function in rats with lipopolysaccharide-induced endotoxaemia by a Src-STAT3-mediated mechanism.

Editor—Sepsis-induced cardiomyopathy contributes to significant morbidity and mortality worldwide. Despite recent advances, the pathophysiology of septic shock is complex and difficult to treat. 1 Rello J. Valenzuela-Sánchez F. Ruiz-Rodriguez M. Moyano S. Sepsis: a review of advances in management. Adv Ther. 2017; 34: 2393-2411 Crossref PubMed Scopus (221) Google Scholar Intralipid® mitigates the cardiodepressant effects of local anaesthetics and ischaemia/reperfusion injury via improved metabolic function and activation of cardioprotective signalling cascades, 2 Partownavid P. Sharma S. Li J. Umar S. Rahman S. Eghbali M. Involvement of opioid receptors in the lipid rescue of bupivacaine-induced cardiotoxicity. Anesth Analg. 2015; 121: 340-347 Crossref PubMed Scopus (17) Google Scholar ,3 Rahman S. Li J. Bopassa J.C. et al. Phosphorylation of GSK-3β mediates intralipid-induced cardioprotection against ischemia/reperfusion injury. Anesthesiology. 2011; 115: 242-253 Crossref PubMed Scopus (116) Google Scholar however its role in sepsis-induced cardiac dysfunction is unknown.