Knockdown of membrane-bound complement regulatory proteins suppresses colon cancer growth in mice through inducing tumor cell apoptosis

Guanghua Tang,Linyue Pan,Zhixiang Wang,Hua Zhu,Yong Yang,Zijian Wang,Hongqin Yue,Yuhua Shi, Dichen Wu,Zhilong Jiang,Danbin Jiang

International Immunopharmacology（2023）

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摘要

•mCRPs are upregulated in colon cancer cells by STAT3, STAT6, and p38 MAPK signaling pathways.•Blockade of mCRPs expression by shRNA effectively enhanced colon cancer cell apoptosis in vitro.•Blockade of mCRPs expression by shRNA reduced colon tumor growth in nude mice through increasing C5b-9 deposition and cell apoptosis.

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关键词

Colon cancer,Membrane-bound complement regulatory proteins (mCRPs),Apoptosis,Complement

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