3D heterometallic complex: photocatalytic property and preventive effect on osteoporosis by activating wnt signaling pathway

A new 3D structural compound, namely {[Cd 2 Sr(pdc) 3 (H 2 O) 3 ]} n ·n(DMF) ( 1 , H 2 pdc = 1,4-benzenedicarboxylic acid, DMF = N,N ′-dimethylformamide), has been produced with the raw materials of Cd(NO 3 ) 2 ·4H 2 O, Sr(NO 3 ) 2 and H 2 pdc under solvothermal conditions. Under an irradiation of UV light, 1a displayed outstanding photocatalytic effect for the organic dyes degradation of methylene orange (MO), Rhodamine B (RhB) and methylene blue (MB). In the biological section, the preventive effect and mechanism of new compound on osteoporosis was evaluated and explored. The activation of the FoxO/Wnt pathway in the primary osteoblast was firstly measured with real-time RT-PCR. The accumulation of ROS in the primary osteoblast was also determined with Reactive Oxygen Species Assay Kit.