Identification of a Novel GRHL3/HOPX/Wnt/β-Catenin Proto-oncogenic Axis in Squamous Cell Carcinoma of the Esophagus.

Smitha Rose Georgy,Diar Riyanti Rudiatmoko,Alana Auden,Darren Partridge,Tariq Butt,Seema Srivastava,Nick Wong,Dijina Swaroop,Marina Rose Carpinelli,Feng Yan,Mirjana Bogeski,Stephen M Jane

Cellular and molecular gastroenterology and hepatology（2023）

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摘要

GRHL3 conveys its tumor suppressor function in ESCC through regulating its target gene HOPX, which limits Wnt/β-catenin signaling. Targeted therapies to inhibit this pathway could be a potential treatment strategy for ESCC patients with reduced GRHL3 expression.

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关键词

Cancer Signaling Pathways,RNA Sequencing,Transcriptional Regulation

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