Identification of redundancy between human FcεRIβ and MS4A6A proteins points toward additional complex mechanisms for FcεRI trafficking and signaling.

Katie Bitting,Barry Hedgespeth,Lauren C Ehrhardt-Humbert,Greer K Arthur,Alicia G Schubert,Peter Bradding,Stephen L Tilley,Glenn Cruse

Allergy（2022）

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摘要

Our data suggest the presence of either FcεRIβ or MS4A6A is sufficient for degranulation, indicating that MS4A6A could be an elusive FcεRIβ-like protein in human MCs that performs compensatory functions in allergic disease.

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关键词

IgE,asthma,mast cells

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