Plasma Leptin Is Associated With Amyloid CSF Biomarkers and Alzheimer's Disease Diagnosis in Cognitively Impaired Patients.

Matthieu Lilamand,Elodie Bouaziz-Amar,Julien Dumurgier,Emmanuel Cognat,Claire Hourregue,François Mouton-Liger,Manuel Sanchez,Anne-Cécile Troussière,Matthieu Martinet,Jacques Hugon,Claire Paquet

The journals of gerontology. Series A, Biological sciences and medical sciences（2023）

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摘要

Plasma leptin levels were associated with CSF Aβ and with the diagnosis of AD confirmed by CSF biomarkers, suggesting a molecular interplay between leptin metabolism and brain amyloid deposition.

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关键词

Alzheimer’s disease,Biomarkers,Leptin,Metabolic dysfunction

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