The effect of interictal epileptic discharges and following spindles on motor sequence learning in epilepsy patients.

Toshiki Okadome,Takahiro Yamaguchi,Takahiko Mukaino,Ayumi Sakata,Katsuya Ogata,Hiroshi Shigeto,Noriko Isobe,Taira Uehara

Frontiers in neurology（2022）

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摘要

We found that the increase of IED-coupled spindles correlated with the decrease of sleep-dependent learning effects of procedural memory. Pathological IED-coupled sleep spindles could hinder memory consolidation, that is dependent on physiological sleep spindles, resulting in cognitive dysfunction in patients with epilepsy.

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关键词

focal epilepsy,interictal epileptic discharge,motor sequence learning,non-rapid eye movement sleep,spindle

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