Carbon monoxide-releasing molecule 2 inhibits inflammation associated with intestinal ischemia-reperfusion injury in a rat model of hemorrhagic shock

International Immunopharmacology(2022)

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摘要
•Th1 and Th17 cells were activated and Tregs were inhibited in the inflammatory reaction of intestinal mucosa after IRI.•CORM-2 inhibited proliferation of Th1 and Th17 cells to reduce the release of IFN-γ and IL-17 proteins.•CORM-2 upregulated the expression of an anti-inflammatory factor (IL-10).
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Carbon monoxide-releasing molecule 2,Inflammation,Intestinal ischemia–reperfusion injury,Hemorrhagic shock
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