Activated fibroblasts induce immune escape of TSCC through CCL25/AKT pathway.

Yiting Li,Ken Lin,Xiaobin Ren,Jianguo Xu, Haiming Yuan,Li Bian,Yongwen He

Oral diseases（2022）

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摘要

Activated fibroblasts can induce the high expression of PD-L1 in the oral and tongue squamous cell carcinoma cell line Cal-27 via the CCL25/CCR9/p-Akt axis, to significantly inhibit the proliferation and IFN-γ secretion of T cells and promote the immune escape of tongue squamous cell carcinoma cells.

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关键词

Akt,CCL 25,PD-L1,fibroblast,tongue squamous cell carcinoma cell

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