Role of cytotoxic T cells and PD-1 immune checkpoint pathway in papillary thyroid carcinoma.

Sohini Banerjee,Uma Nahar,Divya Dahiya,Soham Mukherjee,Pranab Dey,Rijuneeta Gupta,Bishan Radotra,Naresh Sachdeva,Ashwani Sood,Sanjay Kumar Bhadada,Anil Bhansali

Frontiers in endocrinology（2022）

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摘要

Increased expression of PD-1 and PD-L1 in the TME of PTC may provide a potential molecular mechanism for tumor survival despite the predominance of CTLs, possibly through their inactivation or exhaustion.

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CD8 T cell,anti tumor immunity,papillary thyroid carcinoma,programmed death-1,tumor microenvironment

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