Prostate Cancer Cells Are Sensitive to Lysosomotropic Agent Siramesine through Generation Reactive Oxygen Species and in Combination with Tyrosine Kinase Inhibitors.

Emily A Garcia,Ilsa Bhatti,Elizabeth S Henson,Spencer B Gibson

Cancers（2022）

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摘要

This suggests that lysomotropic agents such as siramesine in combination with tyrosine kinase inhibitors induces cell death mediated by ROS and could be an effective treatment strategy in advanced prostate cancer.

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关键词

apoptosis,lipid peroxidation,lysosomotrophic drug,siramesine reactive oxygen species

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