Simultaneous dynamic glucose-enhanced (DGE) MRI and fiber photometry measurements of glucose in the healthy mouse brain

Afroditi Eleftheriou,Luca Ravotto,Matthias T. Wyss, Geoffrey Warnock, Anita Siebert,Moritz Zaiss,Bruno Weber

NeuroImage（2023）

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摘要

•Fiber photometry with FRET biosensors complements MRI with cell-specific data.•Data from FRET fiber photometry are consistent with two-photon microscopy ones.•The DGE signal contains a vascular component at short times after injection.•3OMG produces a positive DGE response but depletes intracellular glucose.

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关键词

Glucocest,Fiber photometry,Genetically encoded sensors,Two-photon microscopy,Kinetic modeling

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