Combined Docetaxel/Pictilisib-Loaded mPEGylated Nanocarriers with Dual HER2 Targeting Antibodies for Synergistic Chemotherapy of Breast Cancer.

Wei-Jie Cheng,Shyr-Yi Lin,Kuo-Hsiang Chuang,Michael Chen,Hsiu-O Ho,Ling-Chun Chen,Chien-Ming Hsieh,Ming-Thau Sheu

International journal of nanomedicine（2022）

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摘要

Non-covalent modification with dual distinct epitopes BsAbs on the nanocarriers loaded with dual chemodrugs at a synergistic ratio was expected to be a promising therapeutic platform to overcome the chemoresistance of various cancers and warrants further development for future therapy in the clinical.

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关键词

HER2-positive breast cancer,bispecific antibodies,docetaxel,dual epitopes,nanocarriers,pictilisib

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