Spliceosomal profiling identifies EIF4A3 as a novel oncogene in hepatocellular carcinoma acting through the modulation of FGFR4 splicing.

Juan L López-Cánovas,Natalia Hermán-Sánchez,Maria Trinidad Moreno-Montilla,Mercedes Del Rio-Moreno,Emilia Alors-Perez,Marina E Sánchez-Frias,Víctor Amado,Rubén Ciria,Javier Briceño,Manuel de la Mata,Justo P Castaño,Manuel Rodriguez-Perálvarez, Raúl M Luque,Manuel D Gahete

Clinical and translational medicine（2022）

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摘要

Splicing machinery is strongly dysregulated in HCC, providing a source of new diagnostic, prognostic and therapeutic options in HCC. EIF4A3 is consistently elevated in HCC patients and associated with tumour aggressiveness and mortality, through the modulation of FGFR4 splicing.

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关键词

FGF19,liver cancer,preclinical model,splicing machinery

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