High-resolution ion mobility spectrometry-mass spectrometry for isomeric separation of prostanoids after Girard's reagent T derivatization.

Lieke Lamont,Darya Hadavi,Andrew P Bowman,Bryn Flinders,Dale Cooper-Shepherd,Martin Palmer, Jan Jordens,Ynze Mengerink,Maarten Honing,James Langridge,Tiffany Porta Siegel,Rob J Vreeken,Ron M A Heeren

Rapid communications in mass spectrometry : RCM（2023）

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摘要

The applied derivatization strategy offers high sensitivity and improved stereoisomeric separation for screening of complex biological systems. The high-resolution IMS comparison indicated that the best sensitivity and resolution are achieved by linear and nonlinear IMS, respectively.

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