A cFLIP-flop switch for senolysis

NATURE CANCER（2022）

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摘要

Persistent senescent cancer cells have tumor-promoting potential, making their selective elimination a prime therapeutic objective. The death receptor inhibitor cFLIP has now been shown to counter the susceptibility of senescent cells to DR5-mediated extrinsic apoptosis, which can be therapeutically exploited.

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cflip-flop

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