Polyclonal antibody-induced downregulation of HER1/EGFR and HER2 surpasses the effect of combinations of specific registered antibodies.

Gretchen Bergado-Báez,Narjara Gonzalez Suarez,Lisset Chao García,Dayana Pérez-Martínez, Diana Rosa Hernández-Fernández,Talia Fundora-Barrios, Antonio Rodríguez-Álvarez, Geidy Diana Díaz-Ordaz,Moshit Lindzen,Yosef Yarden,Belinda Sánchez-Ramírez

Frontiers in oncology（2022）

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摘要

Immunization against HER1 and HER2 receptors offers an alternative to passive administration of combinations of MAbs, since vaccination-induced PAbs promote the downregulation of both receptors and they have a higher impact on the survival of tumor cells.

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关键词

HER1,HER2,cytotoxicity,monoclonal antibodies,polyclonal antibodies,receptor degradation,resistance

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