Dissecting the molecular mechanism of cepharanthine against COVID-19, based on a network pharmacology strategy combined with RNA-sequencing analysis, molecular docking, and molecular dynamics simulation.

Jiaqin Liu,Taoli Sun,Sa Liu,Jian Liu,Senbiao Fang,Shengyu Tan, Yucheng Zeng,Bikui Zhang,Wenqun Li

Comput. Biol. Medicine（2022）

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摘要

Our study comprehensively illustrated the potential targets and underlying molecular mechanism of CEP against COVID-19, which further provided the theoretical basis for exploring the potential protective mechanism of CEP against COVID-19.

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关键词

ACE2,COVID-19,Cepharanthine,Molecular docking,Network pharmacology,PI3K-Akt signal pathway,RNA-Sequencing

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