An atlas of the blood virome in healthy individuals

•We identified 56 different viruses from 37 viral families, including 25 human DNA, RNA and retroviruses in 70% of the studied pools.•Anelloviruses are widely distributed and dominate the blood virome in healthy individuals.•Human herpesviruses and GBV-C are commonly prevalent in asymptomatic humans.•The prevalence of RNA viruses often causing acute infection, like HEV, HPIV, RSV and HCoV-HKU1, revealing of a transmissible risk of asymptomatic infection.•Several viruses possible related to transfusion safety were identified, including human Merkel cell polyomavirus, Papillomavirus, Parvovirus B19 and Herpesvirus 8 in addition to HBV and HIV.