Comparison on the clinical features in patients with or without treatment-resistant depression: A National Survey on Symptomatology of Depression report

•The prevalence of treatment-resistant depression (TRD) among recurrent depression in China is 11.1% appropriately.•There were differences between patients with and without TRD, including demographic and clinical characteristics and somatic symptoms.•Depression with more somatic symptoms had a higher risk of TRD.•Some somatic symptoms, including symptoms with bipolar features, were significantly associated with TRD.