Evaluating the causal effect of tobacco smoking on white matter brain aging: a two-sample Mendelian randomization analysis in UK Biobank.

Chen Mo,Jingtao Wang,Zhenyao Ye,Hongjie Ke,Song Liu,Kathryn Hatch,Si Gao,Jessica Magidson,Chixiang Chen, Braxton D Mitchell,Peter Kochunov,L Elliot Hong,Tianzhou Ma,Shuo Chen

Addiction (Abingdon, England)（2023）

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摘要

There appears to be a significant causal effect of smoking on the brain age gap, which suggests that smoking prevention can be an effective intervention for accelerated brain aging and the age-related decline in cognitive function.

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关键词

Brain aging,Mendelian randomization,causal inference,cigarette per day,smoking behaviors,smoking status,white matter fractional anisotropy

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