Blood levels of MCP-1 modulate the genetic risks of Alzheimer's disease mediated by HLA-DRB1 and APOE for Alzheimer's disease.

Jinghan Huang,Thor D Stein,Yixuan Wang,Ting Fang Alvin Ang,Qiushan Tao,Kathryn L Lunetta,Joseph Massaro,Samia C Akhter-Khan,Jesse Mez,Rhoda Au,Lindsay A Farrer,Xiaoling Zhang,Wei Qiao Qiu

Alzheimer's & dementia : the journal of the Alzheimer's Association（2022）

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摘要

Since HLA-DRB1 and APOE are expressed in the BBB, blood MCP-1 released in the peripheral inflammatory cascade may function as a mediator of the effects of HLA-DRB1 rs9271192-AC/CC and APOE ε4 genotypes on AD pathogenesis in the brain via the BBB pathways.

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关键词

Alzheimer's disease,MCP-1,blood,genotypes

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