Bronchial epithelial cell transcriptome shows endotype heterogeneity of asthma in patients with NSAID-exacerbated respiratory disease.

Bogdan Jakiela,Jerzy Soja,Krzysztof Sladek,Marek Przybyszowski,Hanna Plutecka,Anna Gielicz,Sabina Licholai,Alar Aab,Ana Rebane,Grazyna Bochenek

The Journal of allergy and clinical immunology（2023）

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摘要

T2-high signature was found only in one-third of patients with N-ERD, which was similar to what was found in patients with NTA. The proinflammatory endotype, which also occurred in N-ERD, suggests a novel mechanism of severe disease developing on a non-T2 background.

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关键词

Asthma,NSAID–exacerbated respiratory disease,asthma endotypes,bronchial epithelium,gene expression

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