MUC22, HLA-A, and HLA-DOB variants and COVID-19 in resilient super-agers from Brazil.

Erick C Castelli,Mateus V de Castro,Michel S Naslavsky,Marilia O Scliar,Nayane S B Silva,Raphaela N Pereira,Viviane A O Ciriaco,Camila F B Castro,Celso T Mendes-Junior, Etiele de S Silveira, Iuri M de Oliveira, Eduardo C Antonio,Gustavo F Vieira,Diogo Meyer,Kelly Nunes,Larissa R B Matos,Monize V R Silva,Jaqueline Y T Wang,Joyce Esposito,Vivian R Cória,Jhosiene Y Magawa,Keity S Santos,Edecio Cunha-Neto,Jorge Kalil,Raul H Bortolin,Mário Hiroyuki Hirata, Luiz P Dell'Aquila, Alvaro Razuk-Filho, Pedro B Batista-Júnior,Amaro N Duarte-Neto,Marisa Dolhnikoff,Paulo H N Saldiva,Maria Rita Passos-Bueno,Mayana Zatz

Frontiers in immunology（2022）

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摘要

Since the pro-inflammatory basal state in the elderly may enhance the susceptibility to severe Covid-19, we hypothesized that might play an important protective role against severe Covid-19, by reducing overactive immune responses in the senior population.

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关键词

COVID-19,HLA,MUC22,SARS-CoV-2,human leukocyte antigens,immune response,major histocompatibility complex (MCH),resistant genetic variants

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