Fusion gene recurrence in non-small cell lung cancers and its association with cigarette smoke exposure.
Translational lung cancer research(2022)
摘要
This manuscript provides a strong rationale for investigating the molecular mechanisms of cigarette smoke-induced gene fusion formation associated with lung cancer. Novel recurrent fusions associated with cigarette smoke were identified in our study, which could further be investigated for patient stratification, personalized therapy, and therapeutic monitoring.
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关键词
ChimeRScope,Fusion genes,The Cancer Genome Atlas (TCGA),lung adenocarcinoma,smoke-induced gene fusions
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