Effects of dexmedetomidine on hemodynamic, oxygenation, microcirculation, and inflammatory markers in a porcine model of sepsis.

Paulo Carnicelli,Denise Aya Otsuki,Adalberto Monteiro Filho,Marcia Aparecida Portela Kahvegian,Keila Kazue Ida,José Otavio Costa Auler-Jr,Jean-Jacques Rouby,Denise Tabacchi Fantoni

Acta cirurgica brasileira（2022）

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摘要

Dexmedetomidine did not worsen the hemodynamic, metabolic, inflammatory, or sublingual blood flow disorders resulting from septic shock. Despite inducing a better sublingual vessel density, dexmedetomidine initially and transitorily increased the mismatch between oxygen supply and demand.

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Sepsis,Dexmedetomidine,Swine

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