Type 2 Diabetes Mellitus Makes Corneal Endothelial Cells Vulnerable to Ultraviolet A-Induced Oxidative Damage Via Decreased DJ-1/Nrf2/NQO1 Pathway.

Xueling Zhang,Jini Qiu,Feifei Huang,Kun Shan,Chaoran Zhang

Investigative ophthalmology & visual science（2022）

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摘要

Increase of ROS, downregulation of DJ-1/Nrf2/NQO1 expressions, and decrease of Nrf2 nuclear translocation could result in that T2DM makes CECs more vulnerable to oxidative damage.

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关键词

2 diabetes mellitus (T2DM), corneal endothelial cells (CECs), oxidative stress, antioxidant capacity

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