EDP-514 in healthy subjects and nucleos(t)ide reverse transcriptase inhibitor-suppressed patients with chronic hepatitis B.

Jordan J Feld,Eric Lawitz,Tuan Nguyen,Jacob Lalezari,Tarek Hassanein,Paul Martin,Steven-Huy Han,Douglas Dieterich,Jeanne-Marie Giard,Guy De La Rosa,Alaa Ahmad,Ed Luo,Annie L Conery,Nathalie Adda

Antiviral therapy（2022）

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摘要

EDP-514 was well tolerated, had a PK profile supporting once daily dosing, and reduced HBV RNA levels in NUC-suppressed CHB patients.

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关键词

Chronic hepatitis B,capsid assembly modulator,core inhibitor,core protein allosteric modulator,hepatitis B virus,pharmacodynamics,pharmacokinetics,safety

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